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A world first in plasma fractionation

Home References A world first in plasma fractionation

Reference

A world first in plasma fractionation


Since 1901, Instituto Butantan has been producing immunobiologicals for public health purposes and is responsible for the majority of vaccines and sera produced in Brazil. Butantan has a long tradition of developing processes in close collaboration with local and international universities.

As there was no production of plasma-derived medicinal products in Brazil, the Government of Sao Paulo initiated a project to set up a human plasma fractionation plant together with Butantan. One of the key criteria in selecting technology was the ability to develop production processes for new products easily. Ultimately, they selected the full chromatographic process for the plant.

Neste Jacobs has a long history of developing novel processing steps and methods for the plasma fractionation industry. In addition to the traditional Cohn method, we have been involved in developing other plasma fractionation and purification methods, including fully chromatographic processes.

To achieve these results, Neste Jacobs delivered:

  • User Requirement Specification review
  • Concept Design
  • Basic Design
  • Detailed Design supported with local companies
  • Procurement support
  • Lump-sum turn-key automation delivery
Key customer benefits:
  • Reliable and competent design partner bringing continuity to the engineering
  • EMA- and ANVISA-compliant design solutions
  • Full evaluation of URS
  • Modular design allowing easy expansions
  • Planning and obtaining official permissions
  • Opportunity to develop new technologies and solutions with co-development partner